To investigate sensory functions in mosquitoes, we introduced into An. gambiae the QF2/QUAS binary expression system we originally developed for Drosophila (Potter, 2010; Riabinina, 2015; Riabinina 2016, Riabinina, 2016). The QF2/QUAS system requires two components: the QF2 transcription factor expressed in a tissue of interest, and a QUAS-geneX effector (or reporter) transgene (Potter, 2010; Riabinina, 2015). QUAS denotes the DNA binding sites for the QF2 transcription factor. When the two binary components are in the same cell, geneX is robustly expressed. This is highly versatile since once a QF2 line is validated, it can be used to reproducibly and robustly express any effector gene in that tissue by crossing in a new QUAS-geneX line. Moreover, due to transcriptional amplification, geneX levels are often higher than what could be achieved by direct promoter–geneX fusions, which is particularly useful for capturing expression of chemosensory genes.